Endocrine Abstracts

Thyroid hormone (TH) is a major determinant of muscle physiology, and thyroid dysfunctions are leading causes of many myopathies. Precise control of thyroid hormone-dependent transcription is required by multiple cell system, including muscle stem cells, but how this is achieved is still largely unknown. Intracellular TH concentration is determined by a metabolic balance between the activating and inactivating deiodinase enzymes, D2 and D3. In functional combinations, these re...

Purpose: Treatment with tyrosine kinase inhibitors (TKI) has been associated with alterations in circulating thyroid hormone levels, possibly related to perturbations in peripheral thyroid hormone metabolism. In this study, we evaluated the effect of the multi-kinase inhibitor vandetanib on the expression of the three deiodinase selenoenzymes.Materials and Methods: Cell models that endogenously express either D1 (HepG2 and HEK-293), D2 (HeLa and KMH-2) o...

The iodothyronine deiodinases constitute a family of three selenoenzymes regulating the intracellular metabolism of Thyroid Hormones (THs, T4 and T3) and impacting on several physiological processes, including energy metabolism, development and cell differentiation. The type 1, 2 and 3 deiodinases (D1, D2, and D3), are sensitive, rate-limiting components within the TH axis, and rapidly control TH action in physiological conditions or disease. Notably, several human pathologies...